University of California, San Francisco
Year: 2020
Amount: $2,000,000
Status: Completed
Primary Investigator: Sall
Summary
This project aims to investigate the effects of cannabis exposure during developmental stages on various biological systems in rodents. The study is structured into three key areas: brain effects, immune modulation, and sensory system impacts. For the brain effects, the project explores how different administration routes of THC and CBD affect plasma levels in adult and neonatal rats, and how neonatal exposure impacts behavior and neuronal structure in adulthood. Immune modulation research focuses on the effects of prenatal and perinatal exposure to cannabinoids like THC and CBN on immune responses in adult mice. Finally, the sensory system studies examine how cannabinoids affect pain perception and nociceptive neurons. Findings from these studies are expected to enhance understanding of the long-term impacts of cannabis exposure and inform future guidelines and policies for cannabis use during pregnancy and early life.